Parent Project Muscular Dystrophy: Cialis® (Tadalafil)

Parent Project Muscular Dystrophy: Cialis® (Tadalafil): "In Duchenne (and some cases of Becker) the lack of dystrophin causes, among other things, a decrease in nitric oxide, which normally stimulates cGMP and holds blood vessels open during muscle contraction. Without adequate NO levels, it is thought that the muscles of those with Duchenne and Becker may experience “ischemia,” or damage due to a lack of oxygen. By blocking PDE-5, tadalafil may be able to compensate for the loss of NO at the muscle membrane by upregulating cGMP directly and protecting the muscles of those with Duchenne/Becker during exercise."