Tuesday 17 February 2015

» Eplerenone improves cardiac function in Duchenne patients Action Duchenne

» Eplerenone improves cardiac function in Duchenne patients Action Duchenne: "A recent study showed that a specific cardiac drug is able to induce cardiac function improvement in boys with muscular dystrophy and cardiomyopathy. The study is entitled “Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomized, double-blind, placebo-controlled trial.”

“With increasing recognition of the effect of cardiomyopathy on morbidity and mortality in Duchenne muscular dystrophy, improved strategies are needed to change the natural history of declining left ventricular systolic function and to attenuate its sequelae,” wrote the research team.

Eplerenone is a cardiac medication, used alone or in combination with other drugs to treat high blood pressure. In this study, the authors evaluated the efficacy of eplerenone in patients suffering from DMD and early myocardial disease.Interestingly, in patients taking eplerenone, a significant decrease in the decline in cardiac function was only observed after at least 6 months of therapy.

“Our findings suggest that early treatment with eplerenone attenuates decline in cardiac function, which is a leading cause of death in Duchenne muscular dystrophy,” wrote the research team."



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